In theory, these supplements have the potential to slow cartilage deterioration in the joints, and to reduce pain in the process. In follow-up results of the study released in , these supplements improved pain and function, although no better than a placebo or the NSAID drug celecoxib.
A multinational study called the MOVES trial found the combination of glucosamine and chondroitin as effective at relieving knee OA pain and swelling as celecoxib, without the side effects. And another study found the combination helped reduce joint space narrowing--a sign of cartilage degeneration. Reviews of studies have yielded mixed results about these supplements. The difference in outcomes may be due to the variety of supplement types and doses researchers used.
Studies have also differed on which of these supplements offers the greatest benefit for OA. Some find chondroitin to be superior, others favor glucosamine, while still others prefer a combination of the two. The ideal form of glucosamine has also caused dissent in the research community.
Some studies show an advantage to glucosamine sulfate; others to glucosamine hydrochloride. One study that compared the two glucosamine forms head to head found no real difference between them.
Mayo Clinic researchers agree, saying that evidence supports trying glucosamine sulfate — not hydrochloride — with or without chondroitin sulfate for knee OA. Glucosamine and chondroitin are considered safe, with no serious side effects reported in studies. However, these supplements can interact with blood thinners like warfarin Coumadin. They might also affect blood sugar levels, and one small study found they raise eye pressure, which could increase the risk for glaucoma.
If you have diabetes or glaucoma, you may need to avoid these supplements, or have your doctor monitor your blood sugar levels and eye pressure more closely while you take them. That means that there isn't strong evidence that benefits outweigh risk, but the supplement could be helpful for people with OA. Also, be patient. Get involved with the arthritis community. Every gift to the Arthritis Foundation will help people with arthritis across the U. Join us and become a Champion of Yes.
There are many volunteer opportunities available. Take part to be among those changing lives today and changing the future of arthritis. Help millions of people live with less pain and fund groundbreaking research to discover a cure for this devastating disease. Please, make your urgently-needed donation to the Arthritis Foundation now! Honor a loved one with a meaningful donation to the Arthritis Foundation. We'll send a handwritten card to the honoree or their family notifying them of your thoughtful gift.
I want information on ways to remember the AF in my will, trust or other financial planning vehicles. Believe it or not, there are no natural food sources for glucosamine. This is probably another reason why glucosamine supplements are the 2nd most popular dietary supplement taken. Strenuous activity, physical work, natural aging, and even being just a little overweight can put a lot of extra stress on our joints. In fact, being overweight by as little as 5 pounds may put an extra pounds of extra force on your knees.
To counteract the issues of joint deterioration, to keep your body in motion, to keep you active and flexible, Flex helps lubricate active joints, nourishes and strengthens connective tissues, and helps reduce joint inflammation associated with physical activity. Flex contains no soy, only has to be taken once a day, contains no stimulants like caffeine and green tea, contains zero nuts, uses vegetarian capsules, manufactured in the U. Our premium Flex formula of glucosamine and boswellia serrata are one of the most effective duos on the market to support your joints and help reduce inflammation often associated with exercise.
This product is not intended to diagnose, treat, cure or prevent any disease. Everyone wants to look good, but of all the benefits collagen has to offer, joint care is one of the most important.
Find out how collagen helps keep you moving and grooving as you should. Your body produces less and less collagen every year, starting in your 20s. Toggle navigation. These treatments are sometimes disappointing for physicians and patients because medications may not provide complete relief and can have unwanted side effects.
Some of these patients may be candidates for nutritional supplements like glucosamine and chondroitin sulfate. Preliminary studies show glucosamine sulfate and chondroitin sulfate to be safe and well tolerated. Common side effects may include:. These side effects are reported in a small portion of patients. However, even substances that are found naturally in the body can have unpredictable results when taken in higher than normal quantities and in different formulations.
This is particularly true with patients who are taking multiple medications or who have other diagnosed illness. For example:. Request an Appointment. Search form Search. Twitter Facebook YouTube. You are here Home Share. What is Glucosamine and Chondroitin Sulfate? Typical dosage is mg for glucosamine sulfate and mg for chondroitin sulfate, taken once daily. For body weight less than lbs, the dose is generally reduced to mg for glucosamine sulfate and mg for chondroitin sulfate.
Duration of treatment has not yet been determined.
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