The findings of this study correlate with the studies published in the literature. When poppy seeds are consumed on a bun or roll, it has been estimated that each roll contains 1—4 g of poppy seeds Lachenmeier et al. Assuming that the average salad contains 3—6 g 1—2 teaspoons of poppy seeds and the average bread bun has between 1. This value cannot be used when relating to young children, the elderly or individuals of poor health Sproll et al.
With respect to the values of morphine obtained in this work for harvested seeds, seeds on top of a bread roll and seeds heated with no matrix Table 10 and taking into account the weights of poppy seeds used in a variety of food products mentioned above, the morphine ingested will not exceed the ARfD determined by the EFSA.
Table Comparison of alkaloids identified on harvested and thermally processed poppy seeds. This update related to the detection of morphine, codeine, oripavine, noscapine, and papaverine in poppy seed samples whereas, the previous report related only to the levels of morphine entering the food chain.
Codeine values were given in relation to morphine equivalents, using a conversion factor of 0. Noscapine and papaverine were considered in the most recent publication however, the data that was available to the EFSA did not allow for a hazard characterization but they did conclude that the presence of these compounds would not present a health concern.
In relation to the presence of thebaine and oripavine not included in the work of this paper , it was concluded that there was insufficient data to make any assessment. Based on these updated EFSA findings, the presence of the morphine and codeine in the poppy seeds analyzed in this work, would still would still fall below the recommendations outlined.
There is also little or no information on packaging of poppy seeds regarding what, if any, treatment has taken place prior to packaging. Since the ingestion of poppy seeds has been used as reasons for failure of workplace drug testing and roadside drug testing, more should be done to ensure as much information as is possible is available on the preparation methods of the seeds.
The datasets generated for this study are available on request to the corresponding author. This work was approved by the Northumbria University Ethics committee. The university holds a UK Home Office Drug License for the storage and use of controlled drug standards and for the extraction of alkaloids from poppy seeds. The laboratory work, analysis of data and writing was carried out predominantly by MC. JD and JA helped in the design and review of data and interpretation and all parties contributed to the writing and review of the article.
All authors contributed to the article and approved the submitted version. This work was funded with the support from the Department of Applied Sciences, Northumbria University. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
This work was carried out and submitted as part of a Ph. Annett, H. Factors influencing alkaloidal content and yield of latex in the opium poppy Papaver somniferum. History of opium. Askitopoulou, H. Archaeological evidence on the use of opium in the minoan world. Bernath, J ed. Google Scholar. Bonicamp, J. Can a poppy seed food addict pass a drug test?
Bozan, B. Chemical composition and oxidative stability of flax, safflower and poppy seed and seed oils. Carlin, M. Forensic science: roadside drug testing. Control 42, — Northumbria University. Open Sci. Cassella, G. The analysis of thebaine in urine for the detection of poppy seed consumption. Chen, P. The poppy seed defense: a novel solution.
Drug Test. Cone, E. Interpretation of oral fluid tests for drugs of abuse. Ann NY Acad Sci. Cordell, G. Fifty years of alkaloid biosynthesis in phytochemistry. Phytochemistry 91, 29— Duke, J. Utilization of Papaver. EFSA Scientific Opinion on the risks for public health related to the presence of opium alkaloids in poppy seeds. EFSA J. Garnock-Jones, P. Alakloid content of Papaver somniferum subsp.
Grove, M. Morphine and codeine in poppy seed. Food Chem. Gumuscu, A. Evaluation of selected poppy Papaver somniferum L. Eur Food Res Technol. International Narcotics Board Effect of poppy seed consummation on the positive results of opiates screening in biological samples. Legal Med. Kapoor, L. Opium Poppy: Botany, Chemistry and Pharmacology. Katrine, K. Update of the scientific opinion on opium alkaloids in poppy seeds.
Koleva, I. Alkaloids in the human food chain — Natural occurrence and possible adverse effects. Food Res. Krenn, L. Determination of the five major opium alkaloids by reversed-phase high-performance liquid chromatography on a base-deactivated stationary phase. Chromatographia 47, 21— Lachenmeier, D. Poppy seed foods and opiate drug testing - where are we today? Drug Monit. Lahiri, R. Genetic variability and diversity in Indian germplasm of opium poppy Papaver somniferum L. Plants 8, 41— Straightforward analytical method to determine opium alkaloids in poppy seeds and bakery products.
Mahdavi-Damghani, A. Water stress effects on growth, development and yield of opium poppy Papaver somniferum L. Water Manag. The history of opiates. Meadway, C. Opiate concentrations following the ingestion of poppy seed products - evidence for 'the poppy seed defence'. Forensic Sci. Miller, R. More mysteries of opium revealed: years of opiates.
Trends Pharmacol. Moeller, M. Poppy seed consumption and toxicological analysis of blood and urine samples. Mohsin, H. The chemical investigation of Papaver seeds. CrossRef Full Text. Panicker, S. Quantitation of the major alkaloids in opium from Papaver setigerum. Microgram J. Rohrig, T. The determination of morphine in urine and oral fluid following ingestion of poppy seeds. Schiff, P.
Opium and its alkaloids. Smith, M. Morphine and codeine concentrations in human urine following controlled poppy seeds administration of known opiate content. Sproll, C. Guidelines for reduction of morphine in poppy seed intended for food purposes. Stermitz, F. The biosyntheis of opium alkaloids. Alkaloid Interconversions in Papaver somniferum and P. Stranska, I. Analysis of selected poppy Papaver somniferum L.
Crops Prod. Windle, J. Harms caused by China's —17 opium suppression intervention. Drug Policy. The practice is potentially giving young people and those not using injected drugs a low threshold for addiction to narcotic alkaloids, Geoffrey Robinson, a Wellington expert in drug and alcohol treatment, said. The health ministry decided two years ago that given the quantity of poppy seed required to produce a high it was unlikely to become a significant health problem, but Mr Robinson said retailers knew otherwise.
Supermarket owners in many cities have said they are fed up with shoplifters stealing poppy seeds, or shoppers buying sacks of the seeds in bulk to brew into a tea which contains a range of opiates.
Mark Brosnan, the merchandise general manager of Progressive Enterprises, which operates four supermarket chains, said he was withdrawing bulk poppy seed from the shelves. We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the lands where we live, learn, and work. Posted 4 Aug 4 Aug Wed 4 Aug at am. More on:. NZ vaccine mandates kick in, but they're the 'trojan horse' of the far-right movement.
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